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Retinoblastoma is the most common childhood intraocular malignancy. Typical and atypical presentations are key to timely management and survival. The genetics of this complex tumor have assisted in understanding oncogenesis. Management options are quickly changing and improving vision, globe salvage and survival. Retinal vein occlusion (RVO) is a cause of significant visual loss. It is the second most common cause of retinal vascular disorders after diabetic retinopathy. The partial to complete blockage of the central retinal vein (CRVO) or a branch retinal vein (BRVO) creates visual loss initially by macular edema, macular nonperfusion, intraretinal hemorrhages. Later, anastomotic collateral vessels develop. Retinal and anterior segment neovascularization can lead to vitreous hemorrhages, neovascular glaucoma, blindness and severe pain. This discussion will review current literature and management of retinal vein occlusion. |